By holistic, I mean hardware architecture cooperation. Nvidia can hold onto their lead forever if GPU designers fight over what a GPGPU hardware baseline looks like. The current ecosystem fragmentation is not competitive, and future fragmentation probably wouldn't work either. I think the fastest way to kill Nvidia would be a hardware consortium.
What would you expect the hardware consortium to coordinate on? Unified ISA?
Yes they have implementations on top of CUDA but they're maintained by... Intel. They didn't get buy-in for cross-vendor collaboration