I haven't put in enough effort to replicate the experience on GNOME but once I jump ship from Apple I'll have to.
The way macOS treats shortcuts thanks to the separation of Command and Control is great. It even makes Google Docs pretty painless to use because it's mostly like Emacs. Word still tries to hijack the shortcuts so that's suboptimal.
The advantage of doing it this way ('software flow control') is it worked with just TX and RX lines, rather than having to connect up additional wires to indicate when the terminal was busy ('hardware flow control').
stty -ixon