I'm back on it now for endurance sports (trail running + cycling) and the advice is to just take 5g a day and don't worry about cycling off. At 5g/day it takes 4-6 weeks to saturate your muscles.
It does have a noticeable impact on water retention, so this year I cycled off six weeks away from my "A" race and lost 5lbs of water weight. It was a 100 mile mountain ultra so I thought the extra pop on the climbs probably wasn't worth the extra weight over the entire course (but probably was worth it while doing hill reps in training). Next year I'm sticking to shorter stuff where I'll run up more climbs. For those I don't plan to cycle off.
If you're only after the lifting benefits, 3-5g/day is sufficient.
This is giving me flashbacks to using bodybuilding.com forums.. man, long time ago.
It is my 100% always buy supplement. I only have 2 of those now, protein the other. It absolutely helps me think better and feel better throughout the day. Noticeable when I stop taking it. And its dirt cheap. If I had more disposable income I'd have a few others but I went from tons of supplements to basically nothing. I never use PWOs or anything now, even when I do have money.
My regular supplements that I've noticed made any difference is: creatine, vitamin D, and fiber. With vitamin C and protein being situational as needed.
One thing that might help me notice creatine more is that I haven't drank much caffeine for some reason.. and the longer I've been able to put it off or minimize it, the more of an unfair advantage it has become when I've started.
Dosing for gym exercise is different than dosing for excess creatine to reach the brain.
Well studied, checked with my doctor, including for TBI. Obviously everyone should check for themselves.
Cerebral Creatine levels seem to be a different thing.
Creatine and TBI:
https://health.mil/Reference-Center/Publications/2025/09/25/...
https://www.ncbi.nlm.nih.gov/books/NBK209321/
Creatine supplementation for naturally declining creatine levels:
And then there were the discoveries of creatine in the brain in studies.