You say that like its a problem.. its a formidable solution!
Has worked for me for many years now: Just fail2ban-style block (groups of) relays that attempt to send an unsubscribe-link destined for a mailbox that never ever subscribes to anything. Those malicious-compliance folks add these unsubscribe links everywhere because they determined that its a cheap method for reducing blocks. That makes them reliably stand out whenever they hit strictly human-to-human mailboxes that simply never have any reason to "unsubscribe". Its like a honeypot, and all it took was a strict policy about what a tiny fraction of mailboxes can and cannot be used for.