He made a few videos about it last year and the consensus was basically that none of them have a good enough understanding of the hardware to actually be useful for optimizing anything. They end up making a lot of assumptions about how the caching behavior and memory architecture works and kind of insist that it must work the way modern PCs do. And it led to a number of cache misses and RAM bus contention that basically didn't work as well as he can do by hand.
I mean, most of the advances he made in Mario 64 come from having a deep understanding of the game's code, while enjoying the process of coming up with new ways to improve the code. Having an AI go through your hobbie like that (since he's doing it both for the sake of it and for his M64 romhack) is kind of spoiling the fun, I guess?
You really gotta lay off this childish “all or nothing” mindset. You can use AI without it doing all the work for you. You can use AI to work on a hobby. You set the limits the tool is allowed. AI is a tool.