If you want to make it seem as if I'm pissing on people that were doing useful science that's your privilege, but there is a reason we use terms like 'groundbreaking' about discoveries that are different.
As for lost careers: I've been schlepping bits my whole life, and probably an RTX 6000 could re-run that in under a year, and no doubt what I did was of less significance than that done by the lowliest of scientists. Still, I don't derive my sense of self value from what future technology can do any more than I think that a day laborer should compare themselves with a tractor or a combine.
[1]: https://dokumen.pub/the-phd-grind-a-phd-student-memoir-3.htm...
This is a pretty shitty thing to say, and if you think about it for even a few minutes, you'll understand why.