Holmes' mistake was to massively overdo the "fake it til you make it" in a regulated industry where the implications of the lies appal people, as well as to have a product that was never going to work so the lies were more "this car definitely isn't just rolling down the hill" than "the person at the wheel is only for regulatory reasons". If she'd settled for fantasy metrics and self dealing in a real estate play rather than faking medical tests she'd have investors lining up to fund her second venture...
I'm more intrigued by how she managed to keep customers and at least some of her employees believing and how often that mask slipped.
And then an extremely tight circle of people she knew she could manipulate. Liars hate people that see through their lies and get rid of them as soon as possible or otherwise try to ruin them.
I agree with this point. I think that in the investment world, many VCs investing in deep tech are not deeply familiar with the underlying technology. They often say they are betting on the founders, which can inadvertently encourage this behavior, since founders know that their investors are unlikely to scrutinize the technical details too closely.