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The original release was for Amiga and Mac. The C64 version followed around the same time as the PC version, though apparently the C64 version was the original.
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I was running Sim City 2000 inside Win 3.1 on an 386 with 33MHz (I had 16MB of ram though). But it was virtually unplayable.
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Sim City 2000 is a very different (and computationally more demanding) game than the original Sim City.
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In my youth, people would quit Windows 3.1 to run games in DOS, because the overhead of the OS was too much.

Don’t know if that could be an explanation.

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