Python in itself is poorly suited to ever become performant as it lacks the types required. I imagine that causes some issues for effective jit-ing too.
They had a chance to fix this when adding type annotations, but instead of making it "optional/gradual typing" they opted to make it "documentation or linting support", which is obviously the wrong choice, but there were cultural reasons
If it helps python specifically, given that the types themselves are pretty dynamic, who knows. A python integer doesn't map well to a native integer etc. Python really isn't designed for performance, and retrofitting it is hard.