Python is not uniquely dynamic to a degree that would prevent an efficient implementation.

V8 predates strict mode, and handles all the exec/eval, monkey patching and object system abuse you can do in JavaScript just fine. Common Lisp is one of the most dynamic languages in the world and allows you to do ridiculous things in terms of meta-programming and essentially building domain-specific languages into your program, yet it too manages to have ahead-of-time compiled implementations that are very performant. Also PyPy exists.

There are definitely some technical aspects that make it hard to make Python fast, but they are not insurmountable. The reason CPython is slow today is simply because performance has not historically been prioritized by its developers.