"MuPDF versions before 1.28.5 use an implementation of the drand48 family" yeah, ok, so they're basically not doing real encryption. The number of bits in the key space isn't the real story; the keys simply aren't cryptographically random.
I think the claim is hyperbolic, since most people memory-unsafe PDF implementations, but PDF is a monster format, a metaformat that brings in virtually every conceivable display format, and their renderer implementations with them, often poorly-maintained, never-touched reference implementations from the before times. PDF is pretty scary.