Haven't bothered with DS4.1 personally but I've seen reports of running it with native weights on 4x DGX Sparks. Currently ~$30k but last month that setup was ~$20k.

4x 96 GB runs the NVFP4 quants, which are indistinguishable from Q8 in real-world performance for this particular model. That's not always true but DeepSeek is unusually quantization-friendly. Also remember that a big chunk of the model consists of engrams that can live in system RAM or even on an SSD if necessary.

I imagine the various GGUFs are still pretty impressive, but haven't tried them myself.