Plus all the other vanilla advantages: fewer dependencies, lower maintenance, less retraining, etc…
Of course, there is the question of "the human can still understand what is going on", but it's not clear the new frameworks are optimizing for that...
Now that you don't write the code now, I don't see why I would pick React style libraries unless the codebase is already there.
It's all about how much interactivity you need. A lot of business web apps are full featured commercial software packed in SPA form. You will need a lot of stuff client side and without framework it will be a mess. Unless you write framework yourself but the you are reinventing a wheel.