Before we started this journey (about a year ago), we spent a ton of time cleaning up our codebase, splitting large files (10K+ lines) into files that are no more than 2K lines, things like that. Then we let claude scan our important files and summarize them, add comments for future claude sessions. So we've let it built up tribal knowledge per file and the reasons for things to exist. We tell it all about our operating environment, the country and legal framework etc, so every little piece helps it stay honest and on track.
So to start, do something simple like: Scan the files in this folder for database code and check for queries that loads the entire result set into memory and/or queries that loads all columns. Suggest which queries we can filter better or reduce columns being transferred. Once done, also check real db row counts, compare them with the queries in these files and check if they might benefit from an index or partitioning/sharding. Also check for queries that loads data but their results are not used. Don't make changes yet, just do a deep investigation and report back. Feel free to spin up muliple agents to batch the scans.
edit: it goes without saying you need a language with strict typing and a good compiler (we use dotnet). Doing this on python/javascript would be a nightmare.