I want to love Qubes, but it is a lot more heavyweight than I want to pursue. I have no crypto fortune or government/industrial secrets worth stealing, so it would be putting on a lot of pain knowing I am not a person of interest. I already run my development work inside a VM, but that has some papercuts. Going full Qubes would probably get even more annoying.
A security/isolation layer like this I could use for free feels like it would get me so close to the Qubes ideal without having to completely change how I interface with my machine.