In that case it shouldn't be a problem to boost the innate immune system, as long as you have surplus calories to spend. But it could be something else entirely.

Graves’ disease, lupus/SLE, psoriasis, type 1 diabetes, myasthenia gravis, Addison’s disease, Hashimoto, Goodpasture, etc.

You probably know that antibiotic use is rampant in industrial livestock. But do you know precisely why?

Antibiotics aren't just given prophylactically to prevent infections; constant low doses actually *increase the animal's size*. The animals can put more energy into growing larger, and spend less on their immune system.

You can have a Th1 or a Th2 reaction. One produces one kind of reaction and the other produces a different kind of reaction. And they both inhibit the other. It's a mechanism whose purpose (to the degree purposes exist) is to identify which kind of problem you have and apply as much energy as possible to that because they each fight different kinds of enemies. You'll see in the article they say:

> Allergic reactions are caused by a type of immune response known as Th2 response. Unvaccinated mice showed a strong Th2 response and mucus accumulation in their airways. The vaccine quelled the Th2 response and vaccinated mice maintained clear airways

Neither of these are immune (haha) to causing problems. Th1 was historically associated with multiple sclerosis. Obviously if your detection mechanism is broken you will create more and more of the wrong kind because of the fact one kind can beat the other with numbers but also because the wrong one won't even get the mis-detected enemy (which might not even be an enemy - and be harmless) out.

The too-much-detail: https://pmc.ncbi.nlm.nih.gov/articles/PMC27457/

> Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses. Interferon gamma is the main Th1 cytokine. Excessive proinflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this. The Th2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE and eosinophilic responses in atopy, and also interleukin-10, which has more of an anti-inflammatory response. In excess, Th2 responses will counteract the Th1 mediated microbicidal action. The optimal scenario would therefore seem to be that humans should produce a well balanced Th1 and Th2 response, suited to the immune challenge.

> Many researchers regard allergy as a Th2 weighted imbalance, and recently immunologists have been investigating ways to redirect allergic Th2 responses in favour of Th1 responses to try to reduce the incidence of atopy

There's a lot of detail to it. After all, it's an emergent evolved device that we carry, but that's the rough shape of it. You can create one kind of immune response and simultaneously shut down another kind.

A new area of research has opened up. This approach may be more useful for treatment than prevention. It's not really a vaccine; it's more like an induced vaccine response. Keeping the immune system in that state full time might be a problem. But after an infection, that's what's wanted.

I wonder if the vaccine causes inflammatory and other unpleasant responses when administered. If so, I wonder if those responses go away after the last dose, when the three months of protection begin.

Here are the two paragraphs that I found interesting:

> The new vaccine, for now known as GLA-3M-052-LS+OVA, mimics the T cell signals that directly stimulate innate immune cells in the lungs. It also contains a harmless antigen, an egg protein called ovalbumin or OVA, which recruits T cells into the lungs to maintain the innate response for weeks to months.

> In the study, mice were given a drop of the vaccine in their noses. Some recieved multiple doses, given a week apart. Each mouse was then exposed to one type of respiratory virus. With three doses of the vaccine, mice were protected against SARS-CoV-2 and other coronaviruses for at least three months.

That latter term (ectopic lymphoid structure) comes up in connection with persistent inflammation where the immune system sets up camp near the problem point. Is this good or bad? Do these go away once the infection clears up?

It might be worth it, at least during certain times of the year. For much of the winter, for instance, I already seem to have a lot of nasal drainage and other unpleasant symptoms for the whole time, along with the occasional actual infection which is much more unpleasant.

There's certain times when there's big flare-ups of infections such as flu, so maybe giving everyone an annoying vaccine during that time which gives them the sniffles would actually improve things overall.

Not trying to be flip, but why? "Natural" isn't always better, and as the obesity epidemic has shown, our evolutionary past hasn't done a perfect job of preparing us for our current environment.

You might be right, but I'm skeptical that there is any non-extreme limit to something as simple and mechanical as our innate immune system.

I get sick after getting the flu vaccine and feel pretty bad for 1-3 days... then I get the flu anyway because they picked the wrong ones.