Yes exactly. Claude can just go in, extract the compressed game archives, decompile and read the game logic directly for how everything works. ie. You might be curious how certain stats translate into damage. Just do the above and ask Claude "in detail explain from the decompiled code in this folder for game X how certain stats affect damage and suggest builds to maximise damage taking into account character level <10.".

I've found doing this for games to be far more reliable than trying to find internet posts explaining it. I haven't played POE but if it's anything like any other RPG system Claude will do a great job at this.

DRM just stops you launching/connecting to servers if you modified the binary. It does nothing to stop the binary being pulled apart by a bot with no intention of running it.

The place it may fail is obfuscation and server side logic. But generally client side logic, especially in a game with a scripted language backing it, is super easy for claude ot pick apart.