And thankfully it's not how it works. If it were it'd break plugin ecosystems of many apps completely.
$ strace blender-4.4
..
openat(AT_FDCWD, "/usr/lib64/libpython3.13.so.1.0", O_RDONLY|O_CLOEXEC) = 3
...
openat(AT_FDCWD, "/usr/lib/python3.13", O_RDONLY|O_NONBLOCK|O_CLOEXEC|O_DIRECTORY) = 12
...
No issues with plugins