Over time, it supposedly significantly increases the likelihood of certain diseases/conditions.
Peter Attia was one of those people who got by with little sleep, and for years, well into his medical career, was dismissive of those who preached the importance of 8 hours of sleep a day. He then looked into the research, and completely changed his mind:
In other words it's possible to "feel fine" on little sleep and yet be significantly cognitively impaired. Worth measuring that, if possible.
(It might have been Gwern, he's got a big page on the subject.)
My philosophy is: either I'll live to benefit from technology that can repair the damage caused by aging, in which case health micro-optimizations early in life are not that important, OR this won't be achieved within my lifetime, in which case I prefer a short life with concentrated happiness, vitality and intensity in my youth.
You should at least monitor your deep sleep using a smartwatch. Less than 1.5 hours and I would be worried.
I am not too worried about Alzheimer's as it tends to start pretty late in life (I think average onset is around mid-60s?). If I get that and we don't have a reliable cure by then, I wouldn't really mind ending it quickly after getting the diagnosis. I'm a bit more worried about heart disease as that tends to hit earlier.