Games with kernel anti-cheat.
Office 365 (I think this mostly applies to overly complex Excel spreadsheets with lots of macros? There are also a bunch of people here who say LibreOffice has bad UI, or that they (somehow?) have documents that are complex enough that LibreOffice can't display them properly. Openoffice is somewhat better on those fronts, but neither are good enough if it's for actual work).
and no updates planned.