I suspect it won't stop people, and that it won't be much of an issue in a lot of cases. I wouldn't want to be the one to test it in any sort of court though. Not even on the other side of things, where it'll become even more of a nightmare to protect your indie IP on any form of platform which doesn't heavily regulate things.
The code is also copyrighted and owning a license for a game does not make you safe from being sued for pirating that game or its code. It's fine in this case only because the engine was open sourced.
Nothing makes you safe from getting sued.
See also: [1]. You could also reverse engineer in a solid jurisdiction.
I ran C&C Generals in Wine on Linux back in the days. More stable than Windows XP.
(as always, IANAL)
Interoperability falls under what gets filtered out in the filtration step of the test.