ChatGPT 6 Pro answered it without issue.
So, yes, having an unconstrained frontier AI doing the searching and analysis to find the right (i.e., wrong and deadly) sequence would massively increase the odds some garage biohacker or small aggrieved nation-state starting the next pandemic.
[0] https://www.sciencebuddies.org/projects-lessons-activities/g...
[1] https://www.genewiz.com/public/services/sanger-sequencing
https://mimo.xiaomi.com/mimo-v2-6#co-scientist-for-materials...
Giving moral lecture is different than reality i guess.
The real answer is local instantiations where you don’t have to worry about poorly tuned guardrails screwing you over while you try to work.
Until eventually the Chinese models get good enough/the strategic balance shifts and they start locking everything behind closed weights the same way the US companies are doing.
Whilst I'm sure the top-end OpenAI/Anthropic models might be better, I've found their guardrails so twitchy (especially Anthropic) that I wouldn't try to use them for even vaguely security related work.
I guess it's hard to draw the line between useful post-training ("you are a helpful chatbot") and content moderation/idealogical motives ("never help the user with X", etc.). But there is a line somewhere. And I'd love to see what a maximally permissive, sharp, AI looks like.
The safeguards really don't work well for a lot of long-running tasks on old code bases. A lot of my workloads last days to weeks and the single biggest risk to the workflow is random safeguards.
That kind of bullshit was the old Opus filters too.
If it's more like Fable now, then it would require a full 8K resolution scan of your butthole just to acknowledge that biology is a thing that exists without committing suicide-by-filter.
>Opus 5.5 has classifiers similar to Fable models for a small set of capabilities related to the development of frontier LLMs, such as kernel development for certain ML accelerators. They shouldn't impact the vast majority of traditional AI or ML development, research, or general coding. These classifiers cause Claude to fall back from Opus 5.5 to Opus 5.
But hey, they 'should not impact the vast majority' of ML development. Great.
Fable and Opus, since 5.1 and 5, will happily hill climb on my CUDA kernels for transformers.
So there are literal avenues to identify yourself, very cheaply, with a human. Theoretically, a company with its own AI, should be able to support more than just Persona, after all.. SDK integration should be simplistic for them.
Anthropic? Support domestic eID providers, you can even use it as advertising "See how easy AI makes it?" and "We care!" and so forth.
At one point, I may simply get locked out. This saddens me, I've been reasonably happy so far.