The Taliban was repeatedly crushed. All of the leadership was killed many times over. The problem is the Taliban is an idea that transcends individual human members and it can always be reconstituted. It also benefited from being able to harbor supporters in Pakistan, which is a nuclear power the US was not willing to also invade.

There isn't a real analogy there because cartel leaders have no official state support anywhere, let alone in a bordering nuclear power, but even if they did, it hardly seems reassuring from their perspective to know the drug trade will outlive them after they all get killed. It's different when you're deeply religious and believe what you're doing is worth dying for and the larger arc of history is more important than your own life and wellbeing. I don't think drug lords think that way.

I don’t think the technology matters nearly as much as the asymmetry. Iraq had better technology than the Taliban and their military didn’t last a week.

I think the key difference between the Taliban and the cartels is that the Taliban were a bunch of ideologues who actually enjoyed being an insurgency and living under siege in caves, with making money from the drugs trade being a mere means to their real purpose of fighting infidels, whereas the cartel leadership sees wealth and power from controlling the drugs trade as an end, crushing local rivals as a means, and would really rather avoid the sort of conflict that's bad for their medium term business prospects.

I mean, some sort of cartels would bounce back after any "war on drugs" because supply and demand, but the people running them aren't hankering for martyrdom or glory over consolidating their territory and accumulating.

How are they not rational? Violence is a tool. They operate an illegal business so they can’t sue other parties for breach of contract. They can't call the police if they are robbed or file an insurance claim for what was taken. Even the over-the-top violence has a rationale. They aren't punishing the victims as much as they are attempting to broadcast that there is a higher price to be paid than any gain from giving information, to reduce their future losses and enforcement efforts. It isn’t moral or ethical, but I wouldn’t say it is irrational.

The cartels are incredibly rational - what they lack are morals and ethics

Do you have much evidence of them behaving irrationally?

It's a business not an ideology.

I would recommend reading the Freakinomics book or listen to their podcasts on drugs.

TL;DR: drug cartels are run like businesses. They are very rational. But, unlike your boss, their boss can also shoot you in the face if you annoy them too much

A non-aligned population will look out for their own interests and are aware that the attention of the US is temporary but the cuadillismo that lead to cartels are a durable cultural artifact.

  The Battle of Culiacán, also known locally as the Culiacanazo and Black 
  Thursday, was a failed attempt to capture Ovidio Guzmán López, son of Sinaloa 
  Cartel kingpin Joaquín "El Chapo" Guzmán, who was wanted in the United States 
  for drug trafficking.
  
  Around 700 cartel gunmen began to attack civilian, government and military 
  targets around the city, despite orders from Ovidio sent at security forces' 
  request. Massive towers of smoke could be seen rising from burning cars and 
  vehicles. The cartels were well-equipped, with improvised armored vehicles, 
  bulletproof vests, .50 caliber (12.7 mm) rifles, rocket launchers, grenade 
  launchers and heavy machine guns.

https://en.wikipedia.org/wiki/Battle_of_Culiac%C3%A1n

I think a lot of people would be cheering on the destruction of the cartels.